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SafeRabies

Rabies prevention guidance

Practical advice for avoiding rabies and getting prompt care after exposure

Learn how to prevent animal bites, when to use pre-exposure vaccination, and why immediate wound care plus PEP can save lives.

Rabies Prevention, First Aid & PEP

Complete guide to preventing rabies and what to do after exposure. Expert-verified protocols for immediate action.

  • Rabies is preventable—vaccinating pets and avoiding wildlife are key.
  • After a bite/scratch, wash for 15 minutes and seek PEP promptly.
  • PEP is nearly 100% effective when started before symptoms.
  • Community dog vaccination (≥70% coverage) breaks transmission.

Immediate first aid

  1. 1.Wash for 15 minutes with soap and water; irrigate with povidone-iodine if available.
  2. 2.Avoid primary closure of wounds if possible until after RIG is infiltrated (if indicated).
  3. 3.Tetanus prophylaxis ± antibiotics per standard bite-wound care.

World Health Organization

Rabies PEP schedule with HRIG and vaccine days

Unvaccinated exposure

HRIG: 20 IU/kg once, preferably Day 0

Infiltrate into/around all wounds; inject any leftover IM at a site distant from the vaccine site. Give only up to Day 7 after the first vaccine dose. Never mix in same syringe/site as vaccine.

Vaccine (IM, deltoid; thigh ok for small children; never gluteal):

Days 0, 3, 7, 14. Add Day 28 if immunocompromised.

CDC

Previously vaccinated

No HRIG

Give vaccine Days 0 & 3 only

CDC

Clinician notes

Pregnancy/children are not contraindications to PEP.

Avoid gluteal injections.

Separate HRIG and vaccine sites.

CDC

WHO intradermal (ID) option (where used)

Resource-efficient schedule: 0.1 mL ID at 2 sites on Days 0, 3, 7 (Category II/III exposures). Add RIG for Category III. Do not give RIG after Day 7.

World Health Organization

Can PEP wait for observation/testing?

If a healthy dog/cat/ferret can be observed for 10 days or the animal can be tested quickly, public health may advise deferring or discontinuing PEP if the animal stays healthy/tests negative. Wildlife and unknown animals usually require PEP.

CDC

Pre-Exposure Prophylaxis (PrEP) — travelers & high-risk jobs

2 doses on Days 0 & 7.

Then either a one-time titer between year 1–3 or a one-time booster between 3 weeks and 3 years after dose 1, depending on your risk category.

CDC

Pets & community prevention

  • Vaccinate dogs/cats starting at ~12 weeks, then boosters per product/local law.
  • Sustained ≥70% dog vaccination coverage is the key threshold for breaking transmission in communities.
  • Spay/neuter programs reduce roaming and aggression, decreasing bite incidents.
  • Animal control programs should include vaccination clinics and public education.
  • Community education increases responsible pet ownership and timely veterinary care.

WHO Apps

Travel-Specific Rabies Prevention

Pre-Travel Preparation

  • Research rabies risk at your destination using CDC travel health notices.
  • Consider pre-exposure prophylaxis if traveling to high-risk areas for extended periods.
  • Consult a travel medicine specialist 4-6 weeks before departure.
  • Ensure routine vaccinations are up-to-date before travel.
  • Purchase travel insurance that covers medical evacuation and rabies treatment.

During Travel Precautions

  • Avoid contact with all mammals, including pets and wildlife, in rabies-endemic areas.
  • Do not feed or handle stray animals, no matter how friendly they appear.
  • Supervise children closely—they are more likely to approach animals and less likely to report bites.
  • Avoid caves where bats may roost, especially in Southeast Asia and Latin America.
  • Use bed nets in basic accommodations to prevent bat bites while sleeping.

High-Risk Destinations

Over 95% of human rabies deaths occur in Asia and Africa. Highest risk countries include:

  • India (accounts for ~36% of global rabies deaths)
  • Pakistan and Bangladesh
  • Indonesia and other Southeast Asian countries
  • Most African countries, particularly in rural areas
  • Some parts of Latin America and the Caribbean

CDC Travel Health

Occupational Rabies Risks & Prevention

High-Risk Professions

  • Veterinarians, animal technicians, and wildlife biologists
  • Animal control officers and shelter workers
  • Laboratory workers handling rabies virus or specimens
  • Spelunkers (cave explorers) and bat researchers
  • Forest rangers, wildlife officers, and trappers
  • Postal workers and delivery personnel in rural areas

Occupational Prevention Strategies

  • Pre-exposure vaccination is recommended for all high-risk professions.
  • Use appropriate personal protective equipment (PPE) when handling animals.
  • Implement engineering controls like animal restraint devices and barriers.
  • Report all animal bites or exposures immediately to supervisors.
  • Maintain vaccination records and ensure timely booster doses.
  • Participate in regular rabies prevention training and drills.

See our personal & family safety practices guide for at-home and outdoor precautions, and our emergency response steps for what to do if an exposure happens despite precautions.

Employer Responsibilities

  • Provide pre-exposure vaccination at no cost to employees.
  • Develop and implement exposure control plans.
  • Ensure access to post-exposure prophylaxis through occupational health.
  • Maintain supplies of PPE and proper waste disposal systems.
  • Encourage reporting without fear of reprisal.

OSHA/NIOSH Guidelines

What to do after an exposure

1

Clean the wound

Wash 15 minutes with soap + water → Irrigate with povidone‑iodine if available.

2

Assess the animal

Known dog/cat/ferret? Observe 10 days or test promptly. Wildlife/unknown? Start PEP unless advised otherwise.

3

Start indicated care

Unvaccinated: HRIG + vaccine 0,3,7,14 (±28). Previously vaccinated: vaccine 0 & 3. Avoid gluteal injections.

FAQs

Need immediate help?

If you've been exposed to rabies, don't wait. Find a clinic that provides PEP treatment.

Rabies Laws by State

Review vaccination rules, reporting requirements, and animal control regulations in your state.

Compare requirements in Texas, Florida, and California, then continue with our prevention blog, clinic finder, and risk assessment tool.

References

This page summarizes CDC/WHO guidance. Always follow your local health department's advice.

Last reviewed: January 16, 2025 | Sources: CDC, WHO, santacruzhealth.org

Common Rabies Myths & Facts

Myth: You can get rabies from petting a rabid animal

Fact: Rabies is transmitted through saliva entering the body, usually via a bite. Simply touching or petting an animal, even if rabid, does not transmit the virus unless there is an open wound or mucous membrane exposure to saliva.

Myth: Only dogs transmit rabies to humans

Fact: While dogs are the main source globally (up to 99% of transmissions), rabies can be transmitted by any mammal including bats, raccoons, skunks, foxes, and cats. In the Americas, bats are the leading cause of human rabies deaths.

Myth: You can tell if an animal has rabies by looking at it

Fact: You cannot determine if an animal has rabies by appearance alone. Some animals may act aggressively or unusually friendly, while others may show no visible signs. Laboratory testing is required for diagnosis.

Fact: Wound washing saves lives

Immediate and thorough wound washing with soap and water for 15 minutes can reduce the risk of rabies by up to 90%. This simple first aid step is one of the most effective life-saving measures after potential exposure.

Fact: PEP is effective even after delays

While PEP is most effective when started immediately, it can still prevent rabies if administered up to 10 days after exposure, and sometimes even longer in certain circumstances. Never delay seeking medical care.

Global Rabies Elimination Efforts

The Zero by 30 Initiative

The World Health Organization (WHO), World Organisation for Animal Health (WOAH), Food and Agriculture Organization (FAO), and Global Alliance for Rabies Control (GARC) have united under the "United Against Rabies" framework to achieve zero human deaths from dog-mediated rabies by 2030.

Key Strategies

  • Mass dog vaccination campaigns targeting ≥70% coverage in at-risk areas
  • Improved access to affordable, quality-assured PEP and HRIG
  • Enhanced surveillance and reporting systems
  • Increased community awareness and education
  • Dog population management through humane methods
  • Research into new tools and strategies

Progress to Date

  • Several countries in Latin America and the Caribbean have eliminated dog-mediated rabies
  • Southeast Asian countries are making significant progress through vaccination campaigns
  • African nations are expanding vaccination coverage with international support
  • Human rabies deaths have decreased globally, but approximately 59,000 people still die annually

How You Can Help

  • Ensure your pets are vaccinated against rabies
  • Support organizations working on rabies elimination
  • Report suspicious animal behavior to local authorities
  • Educate others about rabies prevention and the importance of pet vaccination
  • If traveling, consider donating to rabies prevention efforts in high-risk areas

WHO/WOAH/FAO/GARC